百日咳患者含有的毒素中除了百日咳毒索(PT)外,另一种毒索影响宿主对cAMP(腺苷-磷酸)新陈代谢是百日咳腺苷酸环化酶(AC)。AC能渗透到真核细胞内,增高细胞内的cAMP功能水平,多核白细胞和巨噬细胞的杀菌功能减弱,助长百日咳的发生。曾有学者诱导出无AC作用的百日咳菌株,动物试验无致病力,将AC因子重新传入菌株中,仍可恢复对小鼠的致病力。作者将AC提纯制出具有基因分子片断的特异成分,这种AC纯制品可用于检查患者是否产生AC抗体,并作为预防接种百日 In addition to pertussis toxin (PT), toxins contained in pertussis patients affect the host metabolism of cAMP (adenosine-phosphate) by pertussis adenylyl cyclase (AC). AC can penetrate into eukaryotic cells, increase the level of intracellular cAMP function, multi-nucleated white blood cells and macrophages bactericidal function weakened, contributing to the occurrence of whooping cough. Some scholars have induced AC without Vaccine pertussis strains, animal experiments without virulence, the AC factor re-introduced into the strain, can still restore the virulence of mice. The authors purify the AC to produce specific components with molecular fragments of genes that can be used to check whether patients have AC antibodies and vaccination as a hundred days