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当接受广谱抗生素治疗的危重病人发生严重出血时,及时确诊是非常关键的。如果出血是由于抗生素引起的,而不是疾病本身表现之一的话,治疗的方法是根本不同的。继发于抗生素的出血可以通过下面几种机制发生:①骨髓抑制与再障造成的血小板减少;②免疫性血小板破坏;③抑制循环中血小板功能;④增强华法令钠的作用;⑤阻断依赖维生素K凝血因子的合成。骨髓抑制及再障最易发生在应用氯霉素的过程中。当再障是一种特异反应的时候,可逆的骨髓抑制是与用药剂量有关的。它的特征
When critically ill patients receiving a broad-spectrum antibiotic experience severe bleeding, timely diagnosis is critical. The treatment is fundamentally different if the bleeding is caused by antibiotics rather than one of the manifestations of the disease itself. Secondary to secondary bleeding can occur through several mechanisms: ① thrombocytopenia caused by myelosuppression and aplastic anemia; ② immune platelet destruction; ③ inhibition of circulating platelet function; ④ enhance the role of warfarin sodium; Synthesis of vitamin K coagulation factors. Myelosuppression and aplastic anemia most likely occur in the course of the application of chloramphenicol. When aplastic anemia is a specific reaction, reversible myelosuppression is dose dependent. Its characteristics