【摘 要】
：
To discover new chemotypes of nematicides with proper toxicological profiles, a series of novel 1,2,3-benzotriazin-4-one derivatives were synthesized and furthe
【机 构】
：
Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science an
【出 处】
：
Chinese Chemical Letters
论文部分内容阅读
To discover new chemotypes of nematicides with proper toxicological profiles, a series of novel 1,2,3-benzotriazin-4-one derivatives were synthesized and further bioevaluated. The bioassay results showed that most of the synthesized compounds were endowed with moderate to good control efficacy against Meloidogyne incognita at 10.0 mg/L in vivo. Among them, compounds 6k and 6p displayed 100%inhibitory activities at this concentration, which implied that they could be used as lead compounds for promising nematicides.
To discover new chemotypes of nematicides with proper toxicological profiles, a series of novel 1,2,3-benzotriazin-4-one derivatives were synthesized and further bioevaluated. The bioassay results showed that most of the synthesized compounds were endowed with moderate to good control efficacy against Meloidogyne incognita at 10.0 mg / L in vivo. Among them, Compounds 6k and 6p displayed 100% inhibitory activities at this concentration, which implied that they could be used as lead compounds for nematicides.
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