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目的:观察单次延长应激(single-prolonged stress,SPS)建立PTSD模型对实验大鼠模后7天后的旷场行为的变化以及中药复方十味温胆汤对其的调节作用。方法:采用旷场实验,观察不同处理组大鼠的行为改变情况。结果:模型组大鼠在直立次数、穿格次数、运动总距离、中央格停留时间方面均明显低于正常大鼠(P<0.05),西药阿普唑组大鼠,经统计在直立次数、穿格次数、中央停留时间方面与模型组有明显差异(P<0.05),而十味温胆汤组大鼠各项指标均明显高于模型组,其中穿格次数、中央格停留时间与模型组具有非常显著的差异(P<0.01),且与正常组及西药组接近(P>0.05)。结论:本课题成功复制了PTSD样大鼠模型,所选取的中药复方十味温胆汤能显著改善PTSD样大鼠的情绪行为变化,其效用与西药阿普唑仑类似。
OBJECTIVE: To observe the change of open-field behavior of PTSD model induced by single-prolonged stress (SPS) for 7 days in model rats and the regulation effect of Shiwei Wendan Decoction. Methods: Open-field experiments were conducted to observe the behavioral changes of rats in different treatment groups. Results: The rats in model group were significantly lower than those in normal rats (P <0.05) in the number of upright, the number of wears, the total distance of exercise, The number of wearing grids and the central residence time were significantly different from those in the model group (P <0.05), while those in the Shiwei Wendan decoction group were significantly higher than those in the model group Group had a significant difference (P <0.01), and with the normal group and western medicine group close (P> 0.05). Conclusion: The PTSD-like rat model was successfully replicated in this study. The decoction of traditional Chinese medicine Shiwei Wendan Decoction can significantly improve the emotional behavior of PTSD-like rats, and its utility is similar to that of western medicine alprazolam.