【摘 要】
：
Objective:To forward the magnetic resonance imaging (MRI) based distance between the deepest tumor invasion and mesorectal fascia (DMRF),and to explore its prognosis differentiation value in cT3 stage rectal cancer with comparison of cT3 substage.Methods:
【机 构】
：
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing),Departme
论文部分内容阅读
Objective:To forward the magnetic resonance imaging (MRI) based distance between the deepest tumor invasion and mesorectal fascia (DMRF),and to explore its prognosis differentiation value in cT3 stage rectal cancer with comparison of cT3 substage.Methods:This was a retrospective,multicenter cohort study including cT3 rectal cancer patients undergoing neoadjuvant chemoradiotherapy followed by radical surgery from January 2013 to September 2014.DMRF and cT3 substage were evaluated from baseline MRI.The cutoff of DMRF was determined by disease progression.Multivariate cox regression was used to test the prognostic values of baseline variables.Results:A total of 804 patients were included,of which 226 (28.1％) developed progression.A DMRF cutoff of 7 mm was chosen.DMRF category,the dock position of the deepest position of tumor invasion (CDTI) and extramural venous invasion (EMVI) were independent predictors for disease progression,and hazard ratios (HRs)were 0.26[95％ confidence interval (95％ CI),0.13-0.56],1.88 (95％ CI,1.33-2.65) and 1.57 (95％ CI,1.13-2.18),respectively,cT3 substage was not a predictor for disease progression.Conclusions:The measurement of DMRF value on baseline MRI can better distinguish cT3 rectal cancer prognosis rather than cT3 substage,and was recommended in clinical evaluation.
其他文献
Objective:To develop and validate a radiomics prognostic scoring system (RPSS) for prediction of progression-free survival (PFS) in patients with stage Ⅳ non-small cell lung cancer (NSCLC) treated with platinum-based chemotherapy.Methods:In this retrospec
Objective:Benefits of adjuvant treatment in pT1N1 gastric cancer (GC) remain controversial.Additionally,an effective biomarker for early GC is the need of the hour.The prognostic and predictive roles of single patient classifier (SPC) were validated in st
Objective:To describe the contemporary trends in total,inpatient,and outpatient expenditure on major subtypes of cancer in different classifications of hospitals in mainland China.Methods:Home page of Inpatient Medical Records (HIMRs) and Hospital Annual
Objective:Chidamide is an oral histone deacetylase subtype-selective inhibitor approved for relapsed or refractory peripheral T-cell lymphoma (PTCL).This phase 1b study evaluated the safety,pharmacokinetics,and preliminary efficacy of chidamide in combina
目的 探究HIV感染前后血浆CCL3水平变化、急性期血浆CCL3水平与CD4细胞数量及病毒载量之间的关系,评估其对HIV感染的疾病进展的预测能力.方法 选取中国医科大学附属第一医院红丝带门诊HIV感染者54例,对其感染前和急性期感染的血浆CCL3、CD4细胞数量以及病毒载量进行检测.结果 HIV感染前后CCL3升高倍数高组的病毒载量明显高于升高倍数低组(P=0.006);急性期血浆CCL3水平高组在感染120天和感染1年时的CD4细胞数量均低于CCL3水平低组(P=0.018 2;P=).0013),且急
目的 为了了解县级以上检测实验室HCV抗体检测能力,研发制备HCV抗体能力验证质控品,开展基层实验室HCV抗体检测能力的室间比对与评估工作.方法 研发制备均一稳定的HCV抗体检测质控样品,组织全国县级以上75家HCV抗体检测实验室开展能力验证,各实验室按照要求在规定时间内完成质控品检测并按时回报结果,以全部回馈结果确定质控品预期结果,以检测水平评价标准差系数(SDI)评估各实验室检测能力.结果 质控品190906～190910均一性与稳定性检验均符合要求;完成能力验证结果回报的70家实验室中,30家(42
目的 观察不同病情状态的HIV感染者外周血趋化因子C-X-C基元受体4(CXCR4)/趋化因子C-X-C基元配体12(CXCL12)的表达情况,并分析其临床意义.方法 纳入2017年1月至2019年12月本院收治97例HIV感染者,采用全自动病毒载量仪检测HIV感染者血浆病毒载量,分别依据病毒载量及CD4细胞水平分组;比较患者外周血CXCR4、CXCL12表达情况,分析二者在不同病情HIV感染者中表达意义.结果 Ⅱ组(100 copies/mL＜病毒载量≤1000 copies/mL)、Ⅲ组(病毒载量＞1
目的 研究一起儿童不明原因感染HIV-1事件的传播链,查找传染源.方法 通过流行病学调查对1例HIV-1感染的儿童进行随访和检测.采用巢式RT-PCR扩增HIV-1 pol基因片段,通过DNA序列构建系统进化树和分子传播网络分析其传播关系.结果 随访调查和检测排除母婴传播和家庭内传播的可能,曾经为患儿主刀的手术医生王某HIV抗体确证检测结果为阳性,且病毒亚型与患儿一致均为CRF01_AE亚型,毒株之间的pol基因距离仅为0.011,在分子传播网络上单独成簇,且两个病例耐药相关基因的突变位点高度一致.结论
目的 研究建立基于HIV免疫磁分离前处理技术的尿液HIV抗体高敏感性检测方法.方法 采用羧基磁珠和HIV特异性抗原通过碳二亚胺缩合反应,优化制备HIV免疫磁珠;采用BCA法对磁珠偶联前后的HIV抗原浓度进行测定,采用ELISA法对HIV免疫磁珠捕获前后的样本中HIV抗体吸光度(OD)值进行检测,采用HRP标记抗原对免疫磁珠捕获后的HIV抗体进行OD值检测,以抗原偶联率与HIV免疫磁珠的抗体捕获效率为指标,建立HIV免疫磁珠在尿液样本中的前处理体系与检测方法;使用100份阴性尿液样本进行Cut-off值设定
目的 探讨MSM急、慢性HIV感染者与MSM中HIV未感染者口腔菌群的变化规律和差异.方法 2019年5-11月,收集15例MSM急性HIV感染者、15例MSM慢性HIV感染者以及15例未感染HIV的MSM健康对照者的咽拭子标本.提取咽拭子基因组DNA进行16S rRNA基因PCR扩增,然后对其V4～V5区域进行测序,并对口腔菌群群落结构及多样性进行差异分析.结果 在门水平上,以厚壁菌门、变形菌门、拟杆菌门和梭杆菌门为主,这四大菌门占据全部菌群成员的90％以上,其中对照组中四大菌门所占比例为91.92％,