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目的研究脑血管病变严重程度与血浆硫化氢(H_2S)水平的相关性。方法选取2014年1月至2015年10月在东莞市厚街医院神经内科进行住院治疗的急性脑梗死患者58例,根据血管狭窄程度分为:轻度狭窄(<70%)、中度狭窄(≥70%)、闭塞;根据血管病变数目分为:单支病变、两支病变、多支病变。同时选取同期在门诊进行健康体检者58例作为对照组,采用分光光度法测定血浆H_2S含量,观察患者血浆H_2S含量的变化趋势,采用t检验,P<0.05差异有统计学意义。结果观察组和对照组血浆H_2S含量分别为(27.89±5.30)μmol/L、(53.78±4.56)μmol/L,观察组明显低于对照组,两组比较具有统计学差异(t=28.200,P=0.000)。轻度狭窄、中度狭窄、闭塞患者血浆H_2S含量分别为(35.72±4.39)μmol/L、(22.43±3.89)μmol/L、(15.29±2.41)μmol/L,两两比较具有统计学差异(t=10.957,P=0.000;t=5.979,P=0.000);单支病变、两支病变、多支病变患者血浆H_2S含量分别为(34.32±4.80)μmol/L、(21.93±3.71)μmol/L、(14.90±2.48)μmol/L,两两比较具有统计学差异(t=9.274,P=0.000;t=6.687,P=0.000)。结论内源性H_2S含量的变化可能参与脑梗死发生的病理生理过程,并与脑梗死发生损伤的程度有着某种联系,其血浆含量的降低可能会削弱其血管保护作用,加重脑血管受损程度,因此选择作用于H_2S生成的药物作为靶点,将为临床治疗缺血性脑血管病提供新的方向。
Objective To study the relationship between the severity of cerebrovascular disease and plasma hydrogen sulfide (H 2 S) levels. Methods Fifty-eight patients with acute cerebral infarction hospitalized in Houjie Hospital of Dongguan City from January 2014 to October 2015 were divided into mild stenosis (<70%), moderate stenosis ≥70%), occlusion; according to the number of vascular lesions are divided into: a single lesion, two lesions, multiple lesions. In the meantime, 58 healthy subjects were selected as control group during the same period. Plasma H 2 S content was measured by spectrophotometry. The trend of H 2 S content in plasma was observed. The t test was used to evaluate the plasma H 2 S content. P <0.05 was considered as statistically significant. Results The contents of H 2 S in the observation group and the control group were (27.89 ± 5.30) μmol / L and (53.78 ± 4.56) μmol / L, respectively. The observation group was significantly lower than the control group = 0.000). The levels of plasma H 2 S in patients with mild to moderate stenosis and occlusion were (35.72 ± 4.39) μmol / L, (22.43 ± 3.89) μmol / L and (15.29 ± 2.41) μmol / L respectively (34.32 ± 4.80) μmol / L, (21.93 ± 3.71) μmol / L, respectively) in patients with single vessel disease, two-vessel disease and multi-vessel disease. L, (14.90 ± 2.48) μmol / L, with statistical significance (t = 9.274, P = 0.000; t = 6.687, P = 0.000). Conclusions The change of endogenous H 2 S content may be involved in the pathophysiological process of cerebral infarction and has a certain relationship with the extent of injury of cerebral infarction. The decrease of plasma content may reduce its vascular protective effect and aggravate the degree of cerebrovascular injury , So the choice of drugs acting on H 2 S as a target will provide a new direction for the clinical treatment of ischemic cerebrovascular disease.