Lichtiger等(1990)报道环孢菌素对治疗严重节段性回肠炎疗效显著,而且对顽固性溃疡性肠炎也有效。作者列举1例连续服用环孢菌素6年后发生溃疡性结肠炎。患者男性,60岁。因患晚期肾病于1984年进行肾移植,术后6个月停用甲基氢化泼尼松,但仍继续服用环孢菌素,使血清中药物浓度中值保持在140μg/L,移植肾功能正常, Lichtiger et al. (1990) reported that cyclosporine has a significant effect on the treatment of severe Crohn’s disease and is also effective against refractory ulcerative colitis. The authors cite one patient who developed ulcerative colitis 6 years after taking cyclosporin continuously. Male patient, 60 years old. Renal transplantation for advanced kidney disease in 1984 and discontinuation of methylprednisolone six months after surgery continued with cyclosporine to maintain the serum median drug concentration at 140 μg / L, renal graft function normal,