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目的:观察热毒宁治疗小儿急性上呼吸道感染的临床疗效及安全性。方法:240例急性上呼吸道感染患儿随机分为治疗组和对照组各120例。两组患儿均给予对症及支持治疗,治疗组在此基础上给予热毒宁0.5～0.8 ml·kg~(-1)·d~(-1)加入5%葡萄糖注射液150ml,ivd,对照组在此基础上给予利巴韦林10～15 mg·kg~(-1)·d~(-1)加入5%葡萄糖注射液150 ml,ivd。疗程均为5 d。比较两组疗效及不良反应发生情况。结果:治疗组总有效率为91.67%,对照组总有效率为75.00%,两组比较,差异有统计学意义(P<0.05)。治疗组退热开始时间、首次体温正常时间及完全退热时间均明显低于对照组(P<0.05),不良反应也明显少于对照组。结论:热毒宁注射液治疗小儿上呼吸道感染临床效果显著,不良反应少,具有良好的临床价值。
Objective: To observe the clinical efficacy and safety of Renduining in treating pediatric acute upper respiratory tract infection. Methods: A total of 240 children with acute upper respiratory tract infection were randomly divided into treatment group (120 cases) and control group (120 cases). The two groups of children were given symptomatic and supportive treatment. On the basis of this, the treatment group was given Radixonin 0.5 ~ 0.8 ml · kg -1 (-1) · d -1 and 5% glucose injection 150ml ivd On the basis of this, ribavirin was given to 150 mg of riboflavin injection at a dose of 10 ~ 15 mg · kg -1 · d -1, ivd. Treatment are 5 d. The curative effect and adverse reaction of the two groups were compared. Results: The total effective rate was 91.67% in the treatment group and 75.00% in the control group. There was significant difference between the two groups (P <0.05). The onset time of antipyretic, first normal body temperature and complete antipyretic time in treatment group were significantly lower than those in control group (P <0.05), and adverse reactions were also significantly less than those in control group. Conclusion: Rendunning injection for the treatment of children with upper respiratory tract infection has significant clinical effects, fewer adverse reactions, with good clinical value.