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目的检测结直肠癌患者手术前的血清癌胚抗原(CEA)、糖类抗原19-9(CA19-9)和肿瘤标记CA242水平,以探讨其对结直肠癌的诊断价值。方法应用电化学发光法检测100例结直肠癌患者和30例结直肠良性疾病患者的CEA、CA19-9和CA242水平。结果结直肠癌患者血清CEA、CA19-9和CA242含量明显高于良性对照组(P<0.05);血清CEA、CA19-9、CA242浓度在结直肠癌Duke’s临床分期中,存在显著性差异(P<0.01),升高程度为Duke’s分期D>C>B>A;不同分化程度的肿瘤血清CEA、CA19-9、CA242浓度变化存在显著性差异(P<0.01),分化程度越高,CA19-9、CA242水平越低,CEA越高。结论CEA、CA19-9和CA242可作为结直肠癌患者临床分期的补充及手术方式选择的参考依据。
Objective To detect the levels of serum carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9) and tumor marker CA242 in patients with colorectal cancer before surgery to investigate their diagnostic value for colorectal cancer. Methods The levels of CEA, CA19-9 and CA242 in 100 patients with colorectal cancer and 30 patients with benign colorectal disease were detected by electrochemiluminescence. Results The serum levels of CEA, CA19-9 and CA242 in patients with colorectal cancer were significantly higher than those in benign control patients (P <0.05). The serum CEA, CA19-9 and CA242 concentrations were significantly different in Duke’s clinical stage (P (P <0.01). The level of Duke’s stage D> C> B> A was significantly different (P <0.01). The higher the level of differentiation, the higher the level of CA19- 9, the lower the CA242 level, the higher the CEA. Conclusion CEA, CA19-9 and CA242 can be used as a reference for clinical staging and selection of surgical methods in patients with colorectal cancer.