一个单独的离子通道每秒可跨膜运输超过一千亿离子,其中比较重要的钙离子,可以引发一系列动态、瞬时并严格控制范围的生化反应,这使其成为维持细胞稳态的重要介质。十多年前,一种非选择性的钙渗透阳离子电导在足细胞的血管紧张素Ⅱ信号的下游被发现,但其分子结构仍未确定。6年前,研究发现瞬时受体电位阳离子通道(TRPC)6的 A single ion channel transports more than 100 billion ions per second across the membrane, with the more important calcium ions triggering a series of dynamic, transient and tightly controlled biochemical reactions that make it an important medium for maintaining cellular homeostasis . More than ten years ago, a nonselective calcium-permeable cation conductance was found downstream of the podocyte’s angiotensin II signal, but its molecular structure has not been established. Six years ago, the study found that the transient receptor potential cation channel (TRPC) 6