论文部分内容阅读
目的监测和评价深圳市南山区2001年麻疹疫苗的初次免疫效果。方法随机选择预防接种门诊接种麻疹疫苗的8月龄儿童86名,分别于免疫前、免疫后1个月采集静脉血,用酶联免疫吸附试验测定麻疹IgG抗体。结果 86名初免儿童免前抗体阳性率22.09%,免后抗体阳性率81.40%,差异有统计学意义(χ2=60.56,P<0.01)。86名初免儿童免前抗体GMT为1∶138,免后为1∶2 864,差异有统计学意义(t=19.52,P<0.01)。免疫成功率为80.23%。对麻疹疫苗免疫后不同性别、不同户籍的抗体阳性率及GMT进行统计分析,差异无统计学意义(P>0.05)。结论南山区麻疹疫苗的基础免疫成功率未达到85%的指标要求,建议麻疹疫苗初免时间提前到6月龄。
Objective To monitor and evaluate the initial immunization effect of measles vaccine in 2001 in Nanshan District, Shenzhen. Methods Eighty-eight-month-old children were randomly selected from vaccination outpatient immunization with measles vaccine. Venous blood was collected before immunization and one month after immunization. Measles IgG antibody was detected by enzyme linked immunosorbent assay. Results The positive rate of premature antibody in 86 children with no immunization was 22.09%, and the positive rate of antibody was 81.40% after immunization. The difference was statistically significant (χ2 = 60.56, P <0.01). There were statistically significant differences in the number of GMTs among the 86 immunized children (1:198 GMT, 1: 2 864) (t = 19.52, P <0.01). The immune success rate was 80.23%. The antibody positive rate and GMT of different sex and different household registration after immunization of measles vaccine were statistically analyzed, the difference was not statistically significant (P> 0.05). Conclusion The success rate of basic immunization of measles vaccine in Nanshan District did not reach the target of 85%. It is suggested that the time to initial immunization of measles vaccine be advanced to 6 months.