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目的:探讨影响宫腔内人工授精(IUI)助孕成功率的因素。方法:回顾性分析418个IUI周期资料,探讨不孕类型、既往监测排卵和指导同房史、输卵管及其环境因素、授精操作时机、子宫内膜厚度、促排卵方案及精液质量对IUI结局的影响。结果:IUI总的周期临床妊娠率为16.5%。有监测排卵、指导同房史的不孕妇女的IUI治疗成功率明显下降,输卵管及其环境异常妇女的IUI成功率显著低于正常妇女,排卵后授精周期的妊娠率高于排卵前授精周期(P<0.05);不同子宫内膜厚度、促排卵方案及精液质量组的IUI成功率无显著差异(P>0.05)。结论:影响IUI临床妊娠率的主要因素是:既往监测排卵、指导同房史、输卵管及其环境因素及授精操作时机。
Objective: To explore the factors influencing the success rate of intrauterine insemination (IUI) assisted pregnancy. Methods: The data of 418 IUI cycles were retrospectively analyzed to investigate the effects of type of infertility, previous monitoring of ovulation, cohort history, fallopian tube and its environmental factors, timing of insemination, endometrial thickness, ovulation induction program and semen quality on IUI outcomes . Results: The total clinical pregnancy rate of IUI was 16.5%. The successful rate of IUI treatment for infertile women who monitored ovulation and guided same-sex history decreased significantly. The IUI success rate of tubal and its abnormal women was significantly lower than that of normal women. The pregnancy rate after fertilization was higher than that before ovulation <0.05). There was no significant difference in IUI success rate between different endometrial thickness, ovulation induction program and semen quality group (P> 0.05). Conclusion: The main factors affecting the clinical pregnancy rate of IUI are: previous monitoring of ovulation, guidance of common-home history, fallopian tube and its environmental factors and timing of insemination.