应用放射免疫测定法检测２０例缺氧缺血性脑病患儿和１５例正常新生儿血浆内皮素（ＥＴ１）浓度，并对１７例患儿进行治疗前后的动态观察。结果显示２０例患儿治疗前ＥＴ１水平为８５１±１１ｎｇ／Ｌ，明显高于正常对照组６０７±３６（Ｐ＜００１）；１７例治疗好转后ＥＴ１水平为６６８±４３ｎｇ／Ｌ，较治疗前８１４±９６ｎｇ／Ｌ明显下降（Ｐ＜００５）；与正常对照无差异（Ｐ＞００５）；重症患者ＥＴ１水平９８６±２３ｎｇ／Ｌ，显著高于轻、中度患者的水平７９５±７８（Ｐ＜００１）。提示ＥＴ１在缺氧缺血性脑病时升高。作者认为在病程中测定ＥＴ１浓度可作为缺氧缺血性脑病诊断并估计预后的辅助指标。 Radioimmunoassay was used to detect plasma endothelin (ET-1) concentrations in 20 children with hypoxic-ischemic encephalopathy and 15 normal newborns. The dynamic changes of ET-1 in 17 children before and after treatment were observed. The results showed that 20 cases of children before treatment ET 1 level was 85.1 ± 1.1ng / L, significantly higher than the normal control group 60.7 ± 36 (P <001); 17 cases of treatment improved ET 1 level of 668 ± 43ng / L, compared with 814 ± 96ng / L before treatment decreased significantly (P <005); no difference with normal control (P> 005); severe The level of ET-1 in patients was 98.6 ± 2. 3ng / L, which was significantly higher than that of mild and moderate patients (795 ± 7.8, P <001). Tip ET 1 increased in hypoxic-ischemic encephalopathy. The authors believe that in determining the duration of ET 1 concentration can be used as hypoxic-ischemic encephalopathy diagnosis and prognosis of the auxiliary indicators.