目的　探讨层粘连蛋白 (LN)和Ⅲ型前胶原 (PcⅢ )与风湿性疾病肺间质病变的关系。方法　病例组为 5 5例风湿性疾病 (包括系统性红斑狼疮、类风湿关节炎等 ) ,健康对照组为 5 5名同性别、年龄相近的患者健康亲属。血清LN和PcⅢ含量的测定采用放射免疫法。结果　所有病例血清LN和PcⅢ水平均较正常值明显升高 (P <0 0 1) ;有呼吸道症状组与无呼吸道症状组肺间质有病变者比较 ,前者血清LN和PcⅢ水平明显高于后者 (P <0 0 1) ;虽然有放射学间质性肺炎证据者血清的LN和PcⅢ水平高于无放射学间质性肺炎者 ,但差异无显著性。肺通气功能障碍者 ,血清LN和PcⅢ的均数也高于无肺通气功能改变者 ,但无统计学意义。相反 ,11例肺二氧化碳弥散功能损害者 ,血清LN和PcⅢ明显高于另外 44例风湿性疾病患者的血清LN和PcⅢ ,有统计学意义 (P <0 0 1)。结论　在风湿性疾病肺脏损害者中 ,血清LN和PcⅢ显著的升高 ;虽然在放射学间质性肺炎者血清LN和PcⅢ的升高无统计学意义 ,但肺弥散功能损害者 ,血清LN和PcⅢ明显高于无肺弥散功能损害者。血清LN和PcⅢ水平的测定 ,对评估风湿性疾病肺间质病变的活动度有意义。 Objective To investigate the relationship between laminin (LN), procollagen type Ⅲ (PC Ⅲ) and pulmonary interstitial disease in rheumatic diseases. Methods Fifty-five rheumatic diseases (including systemic lupus erythematosus and rheumatoid arthritis) were included in the case group and healthy relatives of 55 same-sex and similar-age patients in the healthy control group. Serum LN and PcⅢ levels were determined by radioimmunoassay. Results The levels of serum LN and PcⅢ in all cases were significantly higher than those in normal subjects (P <0.01). The levels of LN and PcⅢ in patients with respiratory symptoms and without respiratory symptoms were significantly higher than those in patients with posterior (P <0.01). Although the serum levels of LN and PcⅢ in patients with radiographic interstitial pneumonia were higher than those without radioseroneal interstitial pneumonia, the difference was not significant. Pulmonary ventilation dysfunction, serum LN and Pc Ⅲ mean is also higher than those without changes in pulmonary function, but no statistically significant. In contrast, the serum LN and PcⅢ in 11 patients with impaired carbon dioxide diffusion were significantly higher than those in 44 patients with other rheumatic diseases (P <0.01). Conclusion Serum LN and Pc Ⅲ levels are significantly elevated in patients with lung damage of rheumatic diseases. Although there is no statistical significance in the serum LN and Pc Ⅲ levels in patients with radiologic interstitial pneumonia, the patients with lung diffuse dysfunction, serum LN and PcⅢ was significantly higher than those without pulmonary function impairment. The determination of serum LN and PcⅢ levels is of significance in assessing the activity of interstitial lung disease in rheumatic diseases.