小檗胺(Berbamine)是小檗科(Betbe-riaceae)小檗属(Berberis)等植物中含有的一种双苄基异喹啉生物碱,有效成份达91%,含水量为9%,其药理作用与粉防已碱和戊脉安相似。本文采用豚鼠心房标本观察小檗对其收缩性、自律性、兴奋性及功能性不应期的影响。实验结果证明,小檗胺能明显地抑制豚鼠心肌收缩力、减慢频率、对抗肾上腺素诱发的自律性及延长功能性不应期,但对兴奋性影响不大。 Berbamine is a bis-benzylisoquinoline alkaloid found in plants such as Berberis of the genus Betbe-riaceae (Berbe-riaceae). Its active ingredient is 91% and its water content is 9%. The pharmacological effects are similar to powder anti-alkali and verapamil. This article uses guinea pig atrium specimens to observe the effects of small pecker on its contractility, self-discipline, excitability and functional refractory period. The experimental results show that berbamine can significantly inhibit the guinea pig myocardial contractility, slow down the frequency of anti-adrenergic induced autonomy and extend the functional refractory period, but little effect on excitability.