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目的:代谢综合征(MS)与左室肥厚(LVH)相关。以往的证据显示,在高血压患者中,低心房利钠肽(ANP)水平是独立于血压的LVH危险因素。虽然已知利钠肽水平在肥胖者中更低,但尚未评价MS患者的血浆ANP水平。此研究目的为评价MS患者的ANP水平,及其与左心室质量(LVM)之间的关系。方法:研究纳入128例原发性高血压患者:51例合并MS,77例无MS。评估临床状况、超声心动图、生化指标、N末端ANP前体(NT-proANP)和αANP水平。结果:合并MS的高血压患者有更高的LVM,且LVH的患病率增高
Aims: Metabolic syndrome (MS) is associated with left ventricular hypertrophy (LVH). Previous evidence shows that in patients with hypertension, low atrial natriuretic peptide (ANP) levels are independent of the LVH risk factors for blood pressure. Although natriuretic peptide levels are known to be lower in obese subjects, plasma ANP levels in MS patients have not been evaluated. The purpose of this study was to evaluate the association between ANP levels in MS patients and left ventricular mass (LVM). Methods: We enrolled 128 patients with essential hypertension: 51 with MS and 77 without MS. Clinical status, echocardiography, biochemical markers, N-terminal ANP precursors (NT-proANP), and αANP levels were assessed. Results: Hypertensive patients with MS had higher LVM and increased prevalence of LVH