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目的:研究急诊血液灌流治疗急性重度有机磷农药中毒(AOPP)的效果。方法:回顾分析86例AOPP患者,其中治疗组37例,对照组49例。对照组进行常规内科治疗,治疗组在常规治疗基础上加用血液灌流。比较2组患者阿托品应用总量、昏迷时间、呼吸机脱机时间、血清胆碱酯酶活力恢复时间、死亡率、住院时间。结果:与对照组比较,治疗组患者阿托品应用总量降低(P<0.05)、昏迷时间及呼吸机使用时间缩短、血清胆碱酯酶活力恢复时间提前、死亡率下降、住院时间缩短,均差异有统计学意义(均P<0.05)。结论:急诊床边血液灌流能迅速缓解症状,减少复能剂及阿托品用量,提高AOPP患者抢救成功率。
Objective: To study the effect of acute hemoperfusion on acute severe organophosphorus pesticide poisoning (AOPP). Methods: A retrospective analysis of 86 cases of AOPP patients, including 37 cases in the treatment group and 49 cases in the control group. The control group received routine medical treatment, and the treatment group combined with hemoperfusion on the basis of routine treatment. The total atropine application, coma time, ventilator offline time, serum cholinesterase recovery time, mortality and hospital stay were compared between the two groups. Results: Compared with the control group, the total amount of atropine in the treatment group was decreased (P <0.05), the coma time and the ventilator use time were shortened, the recovery time of serum cholinesterase was earlier, the mortality rate was decreased and the length of hospital stay was shorter There was statistical significance (all P <0.05). Conclusion: Emergency bedside blood perfusion can quickly relieve symptoms, reduce the amount of energy-supplements and atropine, and improve the success rate of rescue in patients with AOPP.