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为了进行肝癌发病及防治的基础理论研究,复制肝癌模型甚属必要,国内虽有大鼠肝癌模型,但尚未见小鼠肝癌模型的报导。本文采用遵义医学院病理生理教研室提供的615近交系小鼠自发性肝癌经移植而成的移植性肝癌株((?)16I5),接种于同系小鼠,研究其生物学特性。将该瘤株用埋块法移植于17—24克的615小鼠腋部皮下,共50只经过15～25天的潜伏期,局部出现可触及的瘤块,逐渐长大,在两个月时瘤块最大横直径乘积平均为2.38±1.46cm~2,至动物死亡时其乘积平均为4.84cm,重量平均为5.0克,最重者达7.8克。随着瘤块长
In order to carry out the basic theoretical research on the onset and prevention of liver cancer, it is necessary to replicate the liver cancer model. Although there is a rat liver cancer model in China, there is no report on the mouse liver cancer model. In this study, transplanted hepatocellular carcinoma ((?)16I5) was used to transplant 615 inbred mouse spontaneously hepatic carcinoma provided by the Department of Pathophysiology, Zunyi Medical College, and was inoculated into the same mouse to study its biological characteristics. The tumors were implanted in 17-24 g 615 murine subcutaneous fossa, and a total of 50 rats had an incubation period of 15 to 25 days. Locally palpable parenchyma masses were gradually grown up at two months. The product of the largest transverse diameter of the tumor mass averaged 2.38±1.46 cm~2. By the time of death of the animal, the average product was 4.84 cm, and the average weight was 5.0 g, with the heaviest being 7.8 g. With the length of the tumor