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目的：了解中晚期消化系统恶性肿瘤患者输注脐血机体造血和免疫功能的变化。方法：采用对此类患者输注异体同血型脐血100例为脐血治疗组，同类患者60例输注新鲜成人全血作为对照组，检测患者血中T细胞亚群、免疫球蛋白、SOD含量及血象的变化，并用图像分析仪，表达分析输注脐血的后免疫细胞的变化。结果：脐血组输注后较输注前，T3、T4明而增高，T8明显降低，IgM、IgG、IgA增高；SOD明见增高，白细胞、血小板、血红蛋白明显升高，与对照组比较差异均有显著性。个别患者输注脐血后，出现癌细胞重分化现象。结论：脐血输注，促进中晚期消化系统恶性肿瘤患者免疫功能恢复或免疫重建，促进造血功能恢复，可能促进癌细胞重分化。
Objective: To understand the changes of hematopoiesis and immune function of infusion cord blood in patients with advanced malignant tumor of digestive system. Methods: 100 cases of cord blood were treated with allogeneic hematopoietic umbilical cord blood in this kind of patients. 60 cases of the same kind of patients were infused with fresh adult whole blood as a control group. T cell subsets, immunoglobulin, and SOD were detected in the blood of patients. Changes in blood content and content, and the use of image analyzer, expression analysis of changes in the immune cells after infusion of umbilical cord blood. RESULTS: After infusion of umbilical cord blood group, T3 and T4 were significantly higher than those before infusion, T8 was significantly decreased, IgM, IgG, and IgA were increased; SOD was clearly increased, and white blood cells, platelets, and hemoglobin were significantly increased, which was different from that of the control group. Both are significant. After individual patients infused cord blood, re-differentiation of cancer cells occurred. Conclusion: Umbilical cord blood transfusion can promote the recovery of immune function or immune reconstitution in patients with advanced malignant tumors of the digestive system and promote recovery of hematopoietic function. It may promote redifferentiation of cancer cells.