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目的:回顾性分析肾移植受者术后他克莫司(Tac)的血药浓度与肾功能指标血清胱抑素C(SCysC)以及血清肌酐(SCr)的相关性。方法:纳入84例服用Tac的肾移植受者,其中男67例,女17例,收集其Tac血药浓度、SCysC和SCr数据;分别按术后时间、血药浓度分组,将浓度与SCysC、SCr进行Pearson相关分析,比较不同时间段及浓度水平下血药浓度分别与SCysC、SCr的相关性。结果:术后不同时间段内,Tac血药浓度与SCysC、Scr没有显著相关性(P>0.05);不同药物浓度水平组,血药浓度与SCysC、Scr亦没有显著相关性。随着术后时间的延长,Tac血药浓度呈逐渐下降的趋势,SCysC、Scr水平先是降低,术后两年又逐渐上升。结论:Tac血药浓度不影响SCysC和Scr等生化指标对于移植肾功能的评价。
OBJECTIVE: To retrospectively analyze the correlation between plasma concentration of tacrolimus and serum cystatin C (SCysC) and serum creatinine (SCr) in renal transplant recipients. Methods: Eighty-four renal transplant recipients with Tac were enrolled, including 67 males and 17 females. Tac blood concentration, SCysC and SCr data were collected. The data were divided into groups according to time and plasma concentration, SCr Pearson correlation analysis to compare the different time periods and concentration levels of plasma concentration and SCysC, SCr correlation. Results: There was no significant correlation between Tac concentration and SCysC and Scr at different time points after operation (P> 0.05). There was no significant correlation between plasma Tacrolimus concentration and SCysC and Scr at different drug concentration levels. With the extension of postoperative time, the concentration of Tac decreased gradually. The level of SCysC and Scr decreased first and then gradually increased two years later. Conclusion: Tac blood concentration does not affect the biochemical markers such as SCysC and Scr in the evaluation of renal graft function.