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目的 探讨Ｆａｓ 蛋白在胃癌形成与发展过程的作用及其意义。方法 采用免疫组化染色，对２０ 例正常胃粘膜，３８ 例胃粘膜不典型增生，５２ 例胃癌进行Ｆａｓ 蛋白检测。结果 胃粘膜不典型增生与胃癌的Ｆａｓ 蛋白表达均显著高于正常胃粘膜（ Ｐ 均＜ ０ ．０５） 。Ｆａｓ 蛋白表达与胃癌分期，淋巴结转移无相关性。结论 Ｆａｓ 蛋白与胃癌形成有关，与胃癌进展无关。
Objective To investigate the role of Fas protein in the process of gastric carcinogenesis and development and its significance. Methods Immunohistochemical staining was performed on 20 normal gastric mucosa, 38 gastric atypical hyperplasia and 52 gastric carcinoma. Results The expression of Fas protein in gastric dysplasia and gastric cancer were significantly higher than those in normal gastric mucosa (all P <0.05). There was no correlation between Fas protein expression and gastric cancer staging and lymph node metastasis. Conclusion Fas protein is related to the formation of gastric cancer and has nothing to do with the progress of gastric cancer.