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三苯氧胺(Tamoxifen)具有某些雌激素样的作用,可由胞浆转位到胞核,这种抗雌激素受体复合物将长期停留在细胞核中。虽然其最初具有雌激素样作用,但以后由于不能更新产生胞浆雌激素受体,所以最终仍表现为拮抗雌激素的作用。本文报道2例内膜异位症患者曾经过丹那唑或口服避孕药治疗失败后用三苯氧胺治疗的结果。例1,29岁,经腹腔镜检证实为右侧卵巢子宫内膜囊肿破裂,乙状结肠与子宫直肠窝粘连,输卵管似为正常。经丹那唑200mg,每日3次治疗3个月后改为避孕片治疗6个月。复诊时症状仍明显。又用丹那唑9个月。再次腹腔镜检及剖腹探查见整个盆腔致密粘连,行输卵管卵巢成形术并分离粘
Tamoxifen has certain estrogen-like effects that translocate from the cytoplasm to the nucleus, and this anti-estrogen receptor complex will persist in the nucleus. Although initially having an estrogen-like effect, it eventually appears to antagonize the effect of estrogen as it can not be renewed to produce cytoplasmic estrogen receptors. This paper reports the results of two cases of endometriosis patients who have been treated with tazofenamine after treatment with danazol or oral contraceptive failure. Cases 1,29 years old, confirmed by laparoscopy ovarian endometrial cyst rupture, sigmoid colon and uterine rectal fossa adhesion, tubal seems to be normal. Suprandazole 200mg, 3 times a day for 3 months after treatment instead of contraception for 6 months. The symptoms are still evident at referral. And with danazol 9 months. Laparoscopy and laparotomy again to see the entire pelvic dense adhesions, ovarian tuboplasty and separation of sticky