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目的:观察自拟复方中药联合FOLFOX4化疗方案治疗晚期结直肠癌的疗效及毒副反应。方法:选择晚期结直肠癌术后化疗患者40例,随机分为治疗组20例,采用自拟复方中药联合FOLFOX4方案联合治疗,对照组20例,单纯采用FOLFOX4方案化疗。比较两组化疗前后生存质量改善、毒副反应程度、临床常见症状改善、体力状况及血清肿瘤标记物(CEA、CA199、CA724)、肿瘤坏死因子-α(TNF-α)及白介素-12(IL-12)含量以及血常规、肝肾功及心电图等相关检查指标的变化情况。结果:治疗组在降低血清肿瘤标记物CEA、CA199,减轻化疗过程中白细胞减少、贫血、恶心呕吐,改善临床症状等方面均优于对照组,治疗组可明显改善患者生存质量,优于对照组。TNF-α及IL-12治疗组化疗后升高(P<0.05),对照组降低(P<0.05)。结论:自拟复方中药联合FOLFOX4方案对化疗毒副反应具有一定的防治作用,并能降低血清肿瘤标记物水平,同时可以改善患者临床症状和机体一般状况。
Objective: To observe the curative effect and side effects of self-made compound traditional Chinese medicine combined with FOLFOX4 chemotherapy for advanced colorectal cancer. Methods: Forty patients with postoperative chemotherapy for advanced colorectal cancer were randomly divided into treatment group (n = 20), treatment group (n = 20) and FOLFOX4 regimen alone (n = 20). Before and after chemotherapy, the quality of life, the degree of toxic and side effects, the improvement of common clinical symptoms, physical status and serum tumor markers (CEA, CA199, CA724), tumor necrosis factor-α (TNF-α) and interleukin- -12) content and blood, liver and kidney function and ECG and other related indicators of the inspection changes. Results: The treatment group was better than the control group in reducing serum tumor markers CEA, CA199, reducing leukopenia, anemia, nausea and vomiting during chemotherapy, and improving clinical symptoms. The treatment group could significantly improve the quality of life of patients, which was better than the control group . The levels of TNF-α and IL-12 in treatment group were significantly higher than those in control group (P <0.05). Conclusion: The combination of compound traditional Chinese medicine and FOLFOX4 regimen has some preventive and therapeutic effects on the side effects of chemotherapy, and can reduce the level of serum tumor markers and improve the clinical symptoms and the general condition of the patients.