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乙肝病毒(HBV)宫内感染是发展成乙肝表面抗原(HBsAg)慢性携带者重要原因之一,也是导致出生后接种乙肝疫苗失败的主要原因。我国是乙肝高流行区,慢性HBV感染者约1.3亿,广西地区占了相当比例。我国的慢性HBV携带者多始于儿童期感染,而母婴传播是形成慢性HBV感染的重要原因。胎儿期的HBV感染,不仅易形成以后慢性携带状态,且是肝硬化和肝癌的高危因素。因此研究探讨宫内感染HBV免疫接种失败的原因,提高阻断效果,对于保护高危且易感的HBsAg(+)孕妇的新生儿,防止HBV慢性携带,具有深远的实际意义。1.TH1、TH-2细胞与宫内感染HBV的关系TH1、TH2功能平衡是维持机体免疫功能稳定的重要因
Intrauterine infection of hepatitis B virus (HBV) is one of the important reasons for developing chronic carriers of hepatitis B surface antigen (HBsAg), which is also the main reason for the failure of hepatitis B vaccine after birth. China is a high prevalence of hepatitis B, chronic HBV infection of about 130 million, Guangxi accounted for a considerable proportion. Chronic HBV carriers in our country mostly start childhood infection, and mother-to-infant transmission is an important cause of chronic HBV infection. Fetal HBV infection, not only easy to form after the chronic carrying status, and is a high risk factor for cirrhosis and liver cancer. Therefore, it is of far-reaching practical significance to study the reasons for the failure of intrauterine infection of HBV vaccination and to improve the blocking effect for the protection of neonates with high-risk and susceptible HBsAg (+) pregnant women and prevention of chronic HBV infection. 1. TH1, TH-2 cells and intrauterine infection of HBV relationship TH1, TH2 function balance is to maintain the stability of immune function important