恶性肿瘤是人类致死的前几位原因,其治疗失败的主要原因是远处转移和局部复发。RECK基因是新发现的一种基质金属蛋白酶(matrix metallo proteinases,MMPs)抑制剂,其表达可抑制恶性肿瘤侵袭和转移,对其研究能够为肿瘤治疗的应用提供理论帮助。现将RECK基因与肿瘤研究的进展综述如下。 Malignant tumors are the first few causes of human lethality, the main reason for the failure of treatment is distant metastasis and local recurrence. RECK gene is a newly discovered inhibitor of matrix metallo proteinases (MMPs), whose expression can inhibit the invasion and metastasis of malignant tumors, and its research can provide theoretical help for the application of tumor therapy. RECK gene and tumor research progress are summarized below.