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目的：探索阿托品治疗有机磷农药中毒患者体温、脉搏的变化规律。方法：观察比较了５３例不同程度有机磷农药中毒初期及阿托品治疗过程中体温、脉率的变化。结果：中毒初期重度以上中毒者体温偏低，脉搏增快；阿托品治疗过程中体温和脉搏呈上升趋势，其中阿托品适量者的体温上升幅度为３．８％，脉搏增幅为４０．５％，体温峰值时间为用药后１２～１８小时，此后随阿托品用量递减，体温逐渐下降，３～４天恢复正常。阿托品过量者的体温和脉搏增加分别为１１．６％和４９．７％，其峰值不仅高于无并发症组，还高于并发感染组（Ｐ＜０．０５～０．０１）。结论：阿托品治疗过程中如患者体温上升快、幅度大＞１０．０％、脉搏增加值超过４５．０％是判断阿托品过量有价值的体征。
Objective: To explore the changes of body temperature and pulse of atropine in patients with organophosphorus pesticide poisoning. Methods: The changes of body temperature and pulse rate during the early stage of poisoning and the treatment of atropine were investigated in 53 patients with different degrees of organophosphorus pesticide poisoning. Results: In the early stage of poisoning, the temperature was lower and the pulse rate was faster. The body temperature and pulse rate increased during the atropine treatment. The body temperature increased by 3.8% and the pulse rate increased by 40.5% Peak time after treatment for 12 to 18 hours, then with the amount of atropine decreased, body temperature gradually decreased, 3 to 4 days returned to normal. The atropine overdose body temperature and pulse increase were 11.6% and 49.7%, the peak is not only higher than the non-complication group, but also higher than the concurrent infection group (P <0.05 ~ 0.01). CONCLUSIONS: Atropine products such as a rapid increase in body temperature, a magnitude of> 10.0%, and a pulse increase of more than 45.0% are valuable measures of atropine overdose.