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目的探讨Survivin基因在肺癌组织中的表达及其与临床病理特征的关系。方法采用逆转录-聚合酶链反应(RT-PCR)的方法,检测41例手术切除的肺癌组织及其13例癌旁组织中Survivin基因表达。结果 68.29%肺癌组织有Survivin基因表达,癌旁组织中无Survivin基因表达(P<0.01),Survivin基因与肺癌组织病理分级、TNM分期、淋巴结转移正相关,与性别、年龄、吸烟史无明显相关性(P>0.05)。结论 Survivin的表达在肺癌组织的浸润、转移及发展中具有重要意义。
Objective To investigate the expression of survivin gene in lung cancer and its relationship with clinicopathological features. Methods Survivin gene expression was detected in 41 surgically resected lung cancer tissues and 13 paracancerous tissues by reverse transcription-polymerase chain reaction (RT-PCR). Results There was no expression of Survivin gene in 68.29% of lung cancer tissues and no expression of Survivin gene in adjacent tissues (P <0.01). Survivin gene was positively correlated with histological grade, TNM stage and lymph node metastasis of lung cancer, but not with gender, age and smoking history (P> 0.05). Conclusion The expression of Survivin is important in infiltration, metastasis and development of lung cancer.