研究桑黄发酵产物中多糖对荷瘤小鼠的减毒增效作用。通过液体深层发酵技术获得桑黄菌丝体和发酵液,并从中提取胞内、外多糖PIP和PIE,并建立移植性S180肿瘤小鼠模型,分别观察环磷酰胺单用以及与桑黄发酵产物多糖联合应用时抑瘤率、胸腺指数、脾脏指数、体质量以及外周血细胞和IFN-γ含量的变化。结果表明桑黄发酵产物多糖可明显提高化疗小鼠的免疫功能,降低环磷酰胺的毒性,增强其抗肿瘤作用。 To study the effect of polysaccharide from Phellinus igniarius on the attenuation and synergetic effect in tumor-bearing mice. Phellinus igniarius and fermentation broth were obtained by submerged fermentation of liquid, and PIP and PIE were extracted from them. The mice model of transplanted S180 tumor was established, and the effects of cyclophosphamide alone and in combination with Phellinus igniarius The antitumor activity, thymus index, spleen index, body weight and the changes of peripheral blood cells and IFN-γ in the combination of polysaccharides were detected. The results showed that polysaccharide polysaccharide Phellinus igniarius can significantly improve the immunological function of mice treated with chemotherapy to reduce the toxicity of cyclophosphamide and enhance its anti-tumor effect.