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缝隙连接通讯（GapJunctionintercellu－larCommunication，GJIC）是细胞间通讯联系的重要方式之一。当正常细胞出现恶性转化时、GJIC趋于抑制乃至完全消失。了解常规化疗药物在抑癌的同时对靶细胞GJIC功能的影响，有助于加深GJIC在肿瘤生长和转归中作用的认识和探讨，以调节GJ
Gap Junction Intercellu-lar Communication (GJIC) is one of the most important ways to communicate between cells. When normal cells undergo malignant transformation, GJIC tends to inhibit or even completely disappear. Understanding the effect of conventional chemotherapeutic drugs on GJIC function of target cells while suppressing cancer helps to deepen the understanding and discussion of the role of GJIC in the growth and prognosis of tumors to regulate GJ