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目的探讨隐匿性HBV感染人群治疗后体内HBV-DNA含量与血清转换相关性,为隐匿性HBV感染的诊断和预防提供参考。方法对2010年度深圳某医院体检人群中筛查到57例隐匿性HBV感染人群,进行2年核酸定量检测和血清学的跟踪分析。结果核酸定量结果:57例隐匿性HBV感染患者在经过抗病毒治疗或接种乙肝疫苗(乙肝免疫球蛋白)后,2011年和2012年随访监测患者体内病毒含量均值分别为2.74E4 copies/ml和2.73E4copies/ml,高值均低于4E5 copies/ml,相对2010年结果差异无统计学意义(P>0.05)。血清转换结果 :抗病毒治疗或接种乙肝疫苗(乙肝免疫球蛋白)对HBe Ab和HBc Ab等乙肝血清标志物在隐匿性HBV感染人群中分布差异无统计学意义;出现HBs Ab(+)+HBV-DNA(+)感染模式,提示病毒逃逸和/或病毒突变风险增加。结论通常的抗病毒治疗或接种乙肝疫苗可能对DBI的防治效果一般,且可能增加病毒逃逸和/或突变的风险。
Objective To investigate the correlation between serum HBV-DNA levels and serum conversion in patients with occult HBV infection and provide reference for the diagnosis and prevention of occult HBV infection. Methods Fifty-seven patients with occult HBV infection were screened from the 2010 physical examination population in a hospital in Shenzhen. Two-year nucleic acid quantitative analysis and serological follow-up analysis were conducted. Results Nucleic acid quantitative results: In 57 cases of occult HBV infection in patients after antiviral therapy or vaccination of hepatitis B vaccine (hepatitis B immunoglobulin), 2011 and 2012 follow-up monitoring of patients in vivo virus content were 2.74E4 copies / ml and 2.73 E4copies / ml, high values were less than 4E5 copies / ml, relative to the 2010 results showed no significant difference (P> 0.05). Seroconversion Results There was no significant difference in the distribution of hepatitis B serum markers such as HBe Ab and HBc Ab in patients with occult HBV infection after antiviral treatment or vaccination with hepatitis B vaccine (hepatitis B immunoglobulin); HBs Ab (+) + HBV -DNA (+) infection pattern, suggesting an increased risk of escape and / or mutation of the virus. CONCLUSION Conventional antiviral therapy or vaccination of hepatitis B vaccine may have a general effect on the prevention and treatment of DBI and may increase the risk of virus escape and / or mutation.