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目的研究清解汤体内抗甲型流感的作用机制。方法通过动物模型实验研究,设立正常对照组,病毒模型组,利巴韦林组及清解汤高、中、低剂量组,研究清解汤对甲型流感病毒FM1感染小鼠肺炎抑制作用及对甲型流感病毒感染小鼠的死亡保护作用机制。结果清解汤高、中、低剂量各组肺指数抑制率分别为30%、32.5%、27.5%,说明各组均能有效的降低流感病毒FM1感染小鼠肺指数,与对照组对比均有显著性差异(P<0.05);同时,清解汤高、中、低剂量组对流感病毒感染小鼠的死亡保护率分别是30%、40%、20%,延长生命率是35.48%、47.1%、27.1%;清解汤各组可以明显提高流感病毒感染小鼠的存活率,延长存活时间。结论清解汤具有良好的体内抗甲型流感作用,且安全性好,值得在临床上进一步推广应用。
Objective To study the mechanism of anti-influenza A Methods Animal model experimental study, the establishment of normal control group, the virus model group, ribavirin group and Qing Xie Tang high, medium and low dose group to study the Qingying Decoction on influenza A virus FM1 infection in mice pneumonia and Mechanism of death protection on influenza A virus-infected mice. Results The lung index of high, medium and low doses of Qinggan decoction was 30%, 32.5% and 27.5% respectively, which indicated that each group could effectively reduce the pulmonary index of influenza virus FM1 infected mice, compared with the control group (P <0.05). At the same time, the death protection rates of mice in high, medium and low dose Qingling Decoction group were 30%, 40%, 20%, 35.48%, 47.1 %, 27.1% respectively; Qingzhi Decoction can significantly improve the survival rate of mice infected with influenza virus and prolong the survival time. Conclusions Qing Xie Decoction has a good in vivo anti-influenza A effect, and safety, it is worth further promotion in clinical application.