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目的 观察羟考酮复合丙泊酚用于输尿管镜检查的有效性和安全性.方法 输尿管镜检查患者80例随机均分为两组,分别静脉注射芬太尼1 μg/kg和丙泊酚(F组)以及静脉注射羟考酮100 μg/kg和丙泊酚(Q组).评估麻醉和术后镇痛效果,计算丙泊酚总用药量,记录麻醉诱导前(T1)、意识消失时(T2)、输尿管镜置入输尿管时(T3)和术后清醒时(T4)的MAP、HR和SpO2.观察不良反应发生情况.结果 T2时两组患者MAP均较T1时下降(P＜0.05),但组间差异无统计学意义(P＞0.05);T3时F组的MAP较Q组增高(P＜0.05),SpO2较Q组降低(P＜0.05).Q组丙泊酚用量少于F组(P＜0.05),术中体动、呼吸抑制及恶心发生率均低于F组(P＜0.05).结论 与芬太尼复合丙泊酚比较,羟考酮复合丙泊酚麻醉用于输尿管镜检查的镇痛效果好,不良反应少.“,”Objective To observe the efficacy and safety of oxycodone combined with propofol in ureteroscopy.Methods Eighty patients undergoing ureteroscopy were randomly assigned into two groups with 40 cases each.The patients in group F were anesthetized with fentanyl 1μg/kg combined with propofol(group F) and those in group Q with oxycodone 100 μg/kg combined with propofol.The efficacy of anesthesia and postoperative analgesia were evaluated.The MAP,HR and SpO2 before anesthesia(T1),at the times of lost of consciousness(T2),ureteroscope insertion(T3) and awakening from anesthesia(T4) were recorded.Total consumption of propofol was calculated.The complications were observed.Results The MAP of two groups was significantly lower at T2 than that at T1 (P＜0.05),which was not significantly different between groups of F and Q(P＞0.05).Compared with group F,the MAP was lower and SpO2 was higher in group Q at T3 (P＜0.05).Total consumption of propofol was less in group Q than that in group F(P＜0.05).The incidence rates of body moving and respiratory inhibition during operation and nausea were lower in group Q than those in group F(P＜0.05).Conclusion Compared with anesthesia with fentanyl and propofol,anesthesia with oxycodone and propofol for ureteroscopy may provide better analgesia efficacy with less adverse reaction.