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采用双抗体夹心ELISA法检测40例RV肠炎患儿及30例同龄健康儿童血清和大便IL-8的水平。结果:RV肠炎急性期血清和大便IL-8水平显著高于正常对照组(P<0.01),恢复期血清IL-8已降至正常,而大便IL-8水平仍高于正常对照组(P<0.05)。急性期血清和大便IL-8水平在中重症组显著高于轻症组(P<0.01)。提示:IL-8作为重要的炎症介质参与了RV肠炎的发病机制,急性期血清和大便IL-8水平与RV肠炎病情轻重密切相关。
Serum and stool IL-8 in 40 children with RV enteritis and 30 healthy children of the same age were detected by double antibody sandwich ELISA. Results: Serum and stool concentrations of IL-8 in acute phase of RV enteritis were significantly higher than those in normal control group (P <0.01), serum IL-8 level in convalescent phase was reduced to normal while stool IL-8 level was still higher than that in normal control group <0.05). Serum and stool levels of IL-8 in acute stage were significantly higher in moderate and severe group than in mild group (P <0.01). It is suggested that IL-8 is involved in the pathogenesis of RV enteritis as an important inflammatory mediator. Serum and stool IL-8 levels in acute phase are closely related to the severity of RV enteritis.