【摘 要】
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Dear Editor,Deleted in colorectal cancer (DCC) is a single pass transmembrane glycoprotein that was originally identified in humans as a candidate tumor suppres
【机 构】
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State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, Peking Uni
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Dear Editor,Deleted in colorectal cancer (DCC) is a single pass transmembrane glycoprotein that was originally identified in humans as a candidate tumor suppressor (Fearon et al.,1990).DCC belongs to the immunoglobulin superfamily,and the extracellular fragment is composed of four immunoglobulin-like (lg-like) domains followed by six fibronectin type Ⅲ (FN) domains.DCC plays a pivotal role in axon guidance by mediating a combination of attractive and repulsive effects through interactions with the diffusible guidance cue,netrin-1 (Hong et al.,1999) and draxin (Ahmed et al.,2011).
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