报道了慢性肾功能衰竭(CRF)42例及正常对照40人的TRH兴奋试验、馒头餐胰岛素释放试验和皮质醇节律的测定结果。根据肾小球滤过率(GFR)、尿素氮高低分为二组,发现GFR<50ml/min组T_3、T_4降低(P<0.01),胰岛素升高(P<0.01)及皮质醇升高(P<0.05);该组患者TSH对TRH反应减弱,糖耐量曲线减退及呈高胰岛素释放曲线。CRF患者血肌酐与T_3、T_4呈负相关,与胰岛素呈正相关。结果表明CRF患者T_3、T_4值下降可反映肾功能损害程度。CRF患者糖代谢紊乱是多种相互牵制因素合作结果。 Reported 42 cases of chronic renal failure (CRF) and 40 normal control TRH excited test, bread meal insulin release test and cortisol rhythm measurement results. According to glomerular filtration rate (GFR), the level of urea nitrogen was divided into two groups. It was found that the levels of T_3 and T_4 decreased (P <0.01), insulin increased (P <0.01) and cortisol increased in GFR <50ml / P <0.05). In this group, TSH response to TRH weakened, impaired glucose tolerance curve and hyperinsulinism curve. Serum creatinine was negatively correlated with T_3 and T_4 in patients with CRF, and positively correlated with insulin. The results show that CRF patients T_3, T_4 value can reflect the degree of renal damage. The disorder of glucose metabolism in CRF patients is the result of a variety of mutual containment factors.