脓毒症与脓毒症休克定义国际共识(2014年修订,第3版)将脓毒症(sepsis)定义更新为机体对感染的反应失调而导致危及生命的器官功能障碍~([1]),以往关于脓毒症的定义过于强调感染,现在以机体对感染的反应失调和器官功能障碍为核心~([2])。脓毒症通过诱导初始强烈的全身炎症反应而破坏免疫稳态,随后迅速出现代偿性抗炎反应的负反馈,从而导致机体免疫抑制,这种免疫抑制状态的特征 International consensus on the definition of sepsis and septic shock (2014 revised, 3rd edition) Updated sepsis definition to cause life-threatening organ dysfunction due to unresponsiveness of the organism to infection (1) In the past, the definition of sepsis was too much emphasis on infection, and now the body’s response to infection disorders and organ dysfunction as the core ~ ​​([2]). Sepsis destroys immune homeostasis by inducing an initial strong systemic inflammatory response followed by rapid negative feedback of compensatory anti-inflammatory responses, leading to immunosuppression in the body, a hallmark of this immunosuppressive state