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MIM(missing in metasastasis)又称MTSS1(metastasis suppresor 1),是一个新发现的肿瘤抑制基因,其中含有独立的肌动蛋白结合结构域。MIM-B是MIM的同源异构体,都定位于8q24.1,其编码蛋白都具有N末端的IRSP53/MIM同源结构域(IRSP53/MIM homology domain,IMD)和C末端的WH2结构,而WH2和IMD均可与细胞骨架蛋白结合,引起细胞骨架的改变从而调节细胞的生长活动。MIM或MIM-B在某些转移的肿瘤组织中不表达,而在多种正常组织中广泛表达,提示其可能具有肿瘤抑制作用。本文根据最新研究成果综述MIM和MIM-B两种同源异构体基因的结构、功能及抑制肿瘤转移的可能机制。
MIM (missing in metasastasis), also known as MTSS1 (metastasis suppresor 1), is a newly discovered tumor suppressor gene that contains an independent actin binding domain. MIM-B, a MIM homologue, is located at 8q24.1 and encodes both the N-terminal IRSP53 / MIM homology domain (IMD) and the C-terminal WH2 structure. However, both WH2 and IMD bind to cytoskeletal proteins, causing changes in cytoskeleton and thereby regulating cell growth. MIM or MIM-B is not expressed in some metastatic tumor tissues but widely expressed in many normal tissues, suggesting that it may have tumor suppressive effects. This review summarizes the structure, function and possible mechanism of tumor metastasis of MIM and MIM-B based on the latest research results.