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目前,还没有一个评价局限性硬皮病病情活动程度的敏感性或特异性指标,作者研究了可溶性白介素-2受体(sIL-2R)水平与局限性硬皮病病情活动程度的关系。根据疾病活动情况将17例局限性硬皮病患者分成三组,第一组为活动期,出现新皮疹,旧皮疹逐渐扩大,有红斑或呈紫色;第二组为静止期,没有新皮疹,旧皮疹大小无改变,但变软呈棕色;第三组为不确定期,皮损特点介于活动期和静止期之间。用ELISA测定患者血清sIL-2R水平,ELISA中所使用的单克隆抗体抗-Tac和7G7/B6能与sIL-2R分子表面特异抗原决定簇结合。
At present, there is not a sensitive or specific index to evaluate the extent of activity of scleroderma. The authors studied the relationship between the level of soluble interleukin-2 receptor (sIL-2R) and the extent of localized scleroderma. According to the disease activity, 17 patients with localized scleroderma were divided into three groups. The first group was active, a new rash occurred, the old rash gradually enlarged, erythema or purple. The second group was quiescent with no new rash, No change in the size of the old rash, but soft brown; the third group of indefinite period, the characteristics of lesions between active and quiescent period. Serum levels of sIL-2R were measured by ELISA. The monoclonal antibodies anti-Tac and 7G7 / B6 used in ELISA were able to bind to sIL-2R surface-specific epitopes.