患者男性,53岁,患十二指肠溃疡10余年。近期上腹部疼痛明显加重,以甲氰脒呱口服每日三次,每次0.2克,晚上加服0.2克,经一个月,上腹疼痛缓解,饮食正常。以后因疼痛复发,患者自行用药。疼痛时服1～2次。当用药总量达80克时,病人发现头发一片片变白,继而脱落,两个月内脱成直径约1.5～5cm Male patient, 53 years old, suffering from duodenal ulcer for more than 10 years. Recent pain in the upper abdomen significantly aggravating, with carbachosmine oral three times a day, each 0.2 grams, plus 0.2 grams at night, after a month, abdominal pain relief, normal diet. After the recurrence of pain, the patient medication. When taking 1 to 2 times when the pain. When the total amount of medication up to 80 grams, the patient found a piece of hair white, and then fall off within two months into a diameter of about 1.5 ~ 5cm