Based on the application of practical engineering, propagation processes of explosive waves in rock with water well and tunnel are simulated by ANSYS/LS-DYNA software. The evolution of damage in rock is presented. The effect of water on the damage of the concrete slab in a tunnel is compared with damage inflicted without water. The numerical simulation illustrates that water plays an important role in the evolution of damage of the concrete slab in a mine tunnel. In the presence of water in the rock the concrete slab is damaged more severely than without water in rock. The effect of water location in the rock is also considered. It is found that the concrete slab in the tunnel shows various degrees of damage as a function of the different locations of water. Attenuation laws of stress waves over time-space in rock with water are also obtained. Numerical results indicate that, under blast loading, there are three zones in the rock: a crushed zone nearby the explosive charge, a damaged zone and an elastic zone. The conclusions of numerical analysis may provide references for blasting designs and structure protection.