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目的 :探讨肿瘤性异位HCG的作用机理。方法 :应用放射免疫分析 (RIA)方法检测 3 0例原发性肺癌患者血浆及癌组织悬液中人绒毛膜促性腺激素 (HCG和 β HCG)和环核苷酸的含量 .结果 :肺癌患者血清HCG和β HCG含量在术前组明显高于正常对照组 (P <0 .0 1) ,而术后组较术前组显著降低 (P <0 .0 0 1)。癌组织悬液中HCG和 β HCG明显高于肿瘤远端正常肺组织 (P <0 .0 0 1)。同时检测部分患者血浆和癌组织中环核苷酸含量的结果显示肺癌患者血浆环鸟苷酸 (cGMP)显著高于良性肺部疾病组 ,手术后cGMP显著降低 ,而在癌组织悬液中环腺苷酸 (cAMP)显著低于正常组织组 ,总的趋势是血浆和癌组织中cAMP/cGMP比率明显降低 (P <0 .0 5 )。结论 :本文结果提示肿瘤性异位HCG作为一种自分泌因子 ,可能通过环核苷酸这一激素效应的中间环节 ,在肿瘤细胞自身调节生长、分化、生物学行为等方面起促进作用
Objective: To explore the mechanism of tumor ectopic HCG. METHODS: Human chorionic gonadotropin (HCG and β HCG) and cyclic nucleotides were detected in plasma and cancer tissue suspensions of 30 patients with primary lung cancer by radioimmunoassay (RIA). Results: Lung cancer patients The levels of serum HCG and β HCG in the preoperative group were significantly higher than those in the normal control group (P <0.01), while the postoperative group was significantly lower than the preoperative group (P <0.01). HCG and β HCG were significantly higher in tumor tissue suspension than in normal lung tissue (P < 0.01). At the same time, the detection of cyclic nucleotide content in plasma and cancer tissues of some patients showed that the plasma cyclic guanosine monophosphate (cGMP) was significantly higher in patients with lung cancer than in the benign lung disease group, and cGMP was significantly reduced after surgery, while cyclic adenosine was found in cancer tissue suspensions. Acid (cAMP) was significantly lower than the normal tissue group. The general trend was a significant decrease in cAMP/cGMP ratio in plasma and cancer tissues (P < 0.05). Conclusion :The results of this study suggest that tumor heterotopic HCG as an autocrine factor may play a catalytic role in tumor cell self-regulatory growth, differentiation, biological behavior and other aspects through the intermediate link of cyclic nucleotides.