The variations in gas path parameter deviations can fully reflect the healthy state of aero-engine gas path components and units;therefore, airlines usually take them as key parameters for monitoring the aero-engine gas path performance state and conducting fault diagnosis. In the past, the airlines could not obtain deviations autonomously. At present, a data-driven method based on an aero-engine dataset with a large sample size can be utilized to obtain the deviations. However, it is still difficult to utilize aero-engine datasets with small sample sizes to establish regression models for deviations based on deep neural networks. To obtain monitoring autonomy of each aero-engine model, it is crucial to transfer and reuse the relevant knowledge of deviation modelling learned from different aero-engine models. This paper adopts the Residual-Back Propagation Neural Network (Res-BPNN) to deeply extract high-level features and stacks multi-layer Multi-Kernel Maximum Mean Discrepancy (MK-MMD) adaptation layers to map the extracted high-level features to the Reproduce Kernel Hilbert Space (RKHS) for discrepancy measurement. To further reduce the dis-tribution discrepancy of each aero-engine model, the method of maximizing domain-confusion loss based on an adversarial mechanism is introduced to make the features learned from different domains as close as possible, and then the learned features can be confused. Through the above methods, domain-invariant features can be extracted, and the optimal adaptation effect can be achieved. Finally, the effectiveness of the proposed method is verified by using cruise data from dif-ferent civil aero-engine models and compared with other transfer learning algorithms.