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目的:探讨以益气活血化痰立法的黄芪保心汤防治心肌缺血的作用机理。方法:结扎冠状动脉造成大鼠急性心肌缺血损伤模型,以复方丹参滴丸作对照,观察两种药物对心电图、内皮素(ET)、一氧化氮(NO)、血栓素(TXB2)及6-酮-前列腺素F1α(6-keto-PGF1α)的影响。结果:心肌缺血大鼠存在明显的ET/NO、TXB2/6-keto-PGF1α平衡失调,与模型组相比,两种药物均能升高NO、6-keto-PGF1α水平,降低ET、TXB2水平,并能降低缺血心肌心电图ST段上移。结论:黄芪保心汤具有良好的抗心肌缺血作用,其作用机理可能与血管内皮保护效应密切相关。
Objective: To explore the mechanism of Huangqi Baoxin decoction for preventing and treating myocardial ischemia with the principle of replenishing qi and activating blood circulation. METHODS: Acute myocardial ischemic injury in rats was induced by ligation of coronary arteries. Compound Danshen Dripping Pills were used as controls. Electrocardiogram, endothelin (ET), nitric oxide (NO), thromboxane (TXB2), and 6 were observed. The effect of keto-prostaglandin F1α (6-keto-PGF1α). RESULTS: There were significant imbalances of ET/NO and TXB2/6-keto-PGF1α in rats with myocardial ischemia. Compared with the model group, both drugs increased the levels of NO, 6-keto-PGF1α, and decreased ET and TXB2 levels. Levels, and can reduce myocardial ST-segment elevation in ischemic myocardium. Conclusion: Huangqi Baoxin Decoction has good anti-ischemic myocardial effect, and its mechanism of action may be closely related to the protective effect of vascular endothelium.