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目的：进一步探讨口炎康的作用机理及安全性。方法：采用试管稀释法了解抑菌浓度；小鼠扭体法观察药物对小鼠首次扭体时间及次数的影响；小鼠耳肿胀法观察药物对小鼠耳肿胀的抑制率；最大耐受量观察测定观察药物的安全性。结果：对金黄色葡萄球菌、白色念珠菌、铜绿假单胞菌、肺炎克雷伯氏菌等有一定的抑制作用；小鼠耳肿胀的抑制率为46．46％，优于强的松组；镇痛作用不明显；小鼠最大耐受量为100g／kg，是临床用量的277．8倍。结论：说明药物抑制病原及较强的抗炎作用可能就是有效治疗牙龈炎、牙周炎的主要作用机理，而且该药物的安士性较高。
Objective: To further explore the mechanism and safety of Kouyankang. Methods: The antibacterial concentration was determined by tube dilution method; the writhing effect of mice was observed on the time and frequency of the first writhing of the mice; the ear swelling test was used to observe the inhibition rate of the drug on the ear swelling of mice; the maximum tolerated dose Observe and observe the safety of the observed drug. Results: There was a certain inhibition on Staphylococcus aureus, Candida albicans, Pseudomonas aeruginosa, Klebsiella pneumoniae, etc. The inhibition rate of ear swelling in mice was 46.46%, which was superior to prednisone group. Analgesic effect is not obvious; the maximum tolerated dose in mice is 100g/kg, which is 277.8 times of the clinical dosage. Conclusions: The drug-inhibiting pathogens and strong anti-inflammatory effects may be the main mechanism for the effective treatment of gingivitis and periodontitis, and the drug’s ounces are high.