论文部分内容阅读
角化棘皮瘤(KA)是一种少见的皮肤鳞状细胞肿瘤,具有自行消退的特征。一百多年来关于KA是否为一独立疾病或是低度鳞状细胞癌(SCC),已有许多争论。KA早期生长迅速,在4～8周内形成1cm～2cm大的圆顶状丘疹,损害可在其后的4～6个月内完全消退,遗留凹陷性瘢痕。一般认为KA的消退过程是由于细胞凋亡,即细胞程序性死亡所致。目前已注意到原癌基因,特别是bcl-2原癌基因在控制细胞凋亡中起重要作用。 作者采用免疫组化技术对10例增殖型及退化型KA中bcl-2的表达进行了研究,并与10例分化良好的SCC进行比较。所有标本作
Keratoacanthoma (KA) is a rare cutaneous squamous cell tumor with a self-regressing character. For more than one hundred years, there has been much debate about whether KA is an independent disease or low-grade squamous cell carcinoma (SCC). KA grows rapidly in the early stage and forms dome-shaped papules of 1 cm to 2 cm within 4 to 8 weeks. The lesions can completely regress within 4 to 6 months thereafter, leaving sulci scars. It is generally believed that the regression of KA is due to apoptosis, which is the result of programmed cell death. It has been noted that proto-oncogenes, particularly bcl-2 proto-oncogenes, play an important role in controlling apoptosis. The authors used immunohistochemistry to study the expression of bcl-2 in 10 proliferative and degenerative KAs and compared them with 10 well-differentiated SCCs. All specimens