分别用 2 0mg/只和 40mg/只剂量煤焦沥青经气管灌注大鼠。结果染毒 6 0天后 ,大鼠血清丙二醛含量较染毒前显著增加 ,全血谷胱甘肽过氧化物酶活性较染毒前显著降低 ,其变化均与染毒时间、染毒剂量显著相关 ;超氧化物歧化酶活性 ,染毒前后无明显变化 The rats were perfused tracheally with 20 mg / kg and 40 mg / kg of coal tar pitch, respectively. Results After 60 days of exposure, the content of malondialdehyde in serum increased significantly and the glutathione peroxidase activity in whole blood was significantly lower than that before exposure. The changes of MDA were related to the exposure time, Significantly related; superoxide dismutase activity, no significant changes before and after exposure