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目的检测冠心病(CHD)患者、血清淀粉样蛋白(SAA)及白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)和超敏C-反应蛋白(hs-CRP)的变化,探讨其在CHD发病机制中的意义。方法检测22例急性心肌梗死(AMI)、25例不稳定性心绞痛(UA)、30例稳定性心绞痛(SA)、30例健康者血清SAA、IL-6、TNF-α和hs-CRP水平。结果 CHD患者血清SAA、IL-6、TNF-α和hs-CRP水平均较对照组高(P<0.01);并呈AMI>UA>SA的趋势(P<0.05和0.01),且在冠脉单支病变、双支病变、三支病变者逐渐增高(P<0.01);SAA与IL-6、TNF-α和hs-CRP水平显著相关(P<0.01)。结论 SAA、IL-6、TNF-α和hs-CRP可能参与了CHD的发病过程,可作为CHD病情观察的指标,以预防CHD急性冠脉事件的发生。
Objective To investigate the changes of serum amyloid protein (SAA) and interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and high sensitivity C-reactive protein (hs-CRP) in patients with coronary heart disease (CHD) , To explore its significance in the pathogenesis of CHD. Methods Serum levels of SAA, IL-6, TNF-α and hs-CRP were measured in 22 patients with acute myocardial infarction (AMI), 25 patients with unstable angina (UA), 30 patients with stable angina (SA) and 30 healthy controls. Results The levels of serum SAA, IL-6, TNF-α and hs-CRP in CHD patients were higher than those in control group (P <0.01) The single vessel lesion, double vessel lesion and three lesions were gradually increased (P <0.01). SAA was significantly associated with the levels of IL-6, TNF-α and hs-CRP (P <0.01). Conclusions SAA, IL-6, TNF-α and hs-CRP may be involved in the pathogenesis of CHD and may be used as an indicator of CHD in order to prevent the occurrence of acute coronary events in CHD.