论文部分内容阅读
目的探讨咳尔康口服液平喘作用机制。方法采用卵蛋白法致敏大鼠哮喘模型,观察大鼠血清中一氧化氮(NO)、肿瘤坏死因子-α(T NF-α)、丙二醛(MDA)浓度的变化以及超氧化物歧化酶(SOD)的活力。结果与模型组相比,咳尔康口服液可以降低MDA、NO和TNF-α的浓度,增强SOD的活力,差异具有统计学意义(P<0.05)。结论咳尔康口服液的平喘作用与降低NO、TNF-α和MDA的浓度,增强SOD的活力相关。
Objective To investigate the mechanism of Ke’erkang oral liquid antiasthmatic effect. Methods The rat model of asthma was induced by ovalbumin. Serum levels of nitric oxide (NO), tumor necrosis factor-α (T NF-α) and malondialdehyde (MDA) were measured and the effects of superoxide dismutase Enzyme (SOD) activity. Results Compared with the model group, Ke’erkang oral liquid can reduce the concentrations of MDA, NO and TNF-α and increase the activity of SOD, the difference was statistically significant (P <0.05). Conclusion The anti-asthmatic effect of Ke’erkang Oral Liquid is related to decreasing the concentration of NO, TNF-α and MDA and enhancing the activity of SOD.