论文部分内容阅读
目的观察当飞利肝宁片治疗精神病药物所致肝功能损伤的疗效。方法将服用抗精神病药物导致轻度肝功能损伤的80例住院精神病患者随机分为当飞利肝宁片治疗组(治疗组,40例)和护肝片治疗组(对照组,40例),治疗组口服当飞利肝宁片,每次2片,每天3次;对照组口服护肝片,每次4片,每天3次,两组均治疗4周。观察治疗前及治疗1、2、4周后ALT、AST变化情况,比较两组疗效。结果与本组前一时间点比较,两组治疗1、2、4周ALT、AST逐渐降低(P<0.05)。治疗组治愈率、总有效率分别为72.5%、97.5%,对照组治愈率、总有效率分别为62.5%、90.0%,两组治愈率及总有效率差异无统计学意义(P>0.05)。两组均未出现明显不良反应。结论当飞利肝宁片可以安全有效地治疗抗精神病药物所致肝功能损伤。
Objective To observe the effect of Fei Li Gan Ning Tablet on the treatment of psychiatric drugs-induced liver injury. Methods A total of 80 inpatients with mild liver damage caused by antipsychotics were randomly divided into two groups: treatment group (40 cases) and treatment group (control group, 40 cases) The treatment group oral when Fei Li Gan Ning films, each 2, 3 times a day; control group oral administration of liver tablets, each 4, 3 times a day, two groups were treated for 4 weeks. The changes of ALT and AST before and after 1, 2 and 4 weeks of treatment were observed, and the curative effect was compared between the two groups. Results Compared with the previous time point in this group, the ALT and AST decreased gradually (P <0.05) at 1, 2 and 4 weeks after treatment. The cure rate and total effective rate of the treatment group were 72.5% and 97.5% respectively. The cure rate and total effective rate of the control group were 62.5% and 90.0% respectively. There was no significant difference between the two groups in the cure rate and the total effective rate (P> 0.05) . No significant adverse reactions occurred in both groups. Conclusion When Fei Li Gan Ning Tablet can be safely and effectively treated with antipsychotic-induced liver damage.