目的探讨长期接触低浓度氯气对工人肺通气功能的影响。方法某漂精厂工人为暴露组,某机械制造厂工人为对照组,对2组人群进行问卷调查和体格检查,并对2组人群的工作环境分别进行现场空气中氯气浓度检测。问卷内容包括年龄、性别、工龄、吸烟情况(是否吸烟、吸烟年限、吸烟量)、职业史和既往疾病史等,体格检测指标包括血常规、血清C-反应蛋白(CRP)、Ⅰ型血红素氧合酶(HO-1)和用力肺活量(FVC)、第1秒用力肺活量(FEV1.0)和1秒率(FEV1.0/FVC),对2组人群的以上指标进行统计分析。结果暴露组共615名工人,对照组共97名工人,2组人群在年龄、工龄、性别、吸烟状况等的差异均无统计学意义(均P>0.05)。暴露组所在的漂精厂监测点的氯气浓度范围为未检出~0.195 mg/m3,对照组所在的机械制造厂监测点的结果均未检出。除白细胞计数的差异无统计学意义外,暴露组的红细胞计数、血红蛋白含量、血小板计数均低于对照组,单核细胞计数、淋巴细胞计数、血清CRP超临界值率、血清HO-1均高于对照组,差异均有统计学意义(P<0.05或P<0.01)。结论长期接触低浓度氯气,可能会引起肺部炎症,对工人肺通气功能产生不良的影响。 Objective To investigate the effect of long-term exposure to low concentration chlorine on pulmonary ventilation in workers. Methods A worker in bleaching plant was exposed group and a worker at a machinery factory was a control group. Questionnaire and physical examination were conducted on two groups of people, and the working atmosphere of two groups of people were respectively tested for chlorine concentration in the air. The questionnaire included age, sex, length of service, smoking status (whether smoking, smoking duration, smoking amount), occupational history and past disease history, physical examination indicators including blood, serum C-reactive protein (CRP), type I heme Oxygenase (HO-1), forced vital capacity (FVC), forced expiratory volume in one second (FEV1.0) and 1 second rate (FEV1.0 / FVC) were used for statistical analysis. Results There were 615 workers in the exposed group and 97 workers in the control group. There were no significant differences in age, length of service, sex, smoking status among the two groups (all P> 0.05). The concentration of chlorine in the monitoring station of the bleaching plant where the exposure group was located was undetected ~ 0.195 mg / m3, and the results of the monitoring points of the machinery factory where the control group was located were not detected. Except for the difference of leukocyte count was not statistically significant, the exposed group’s erythrocyte count, hemoglobin content and platelet count were lower than the control group, monocyte count, lymphocyte count, serum CRP supercritical rate and serum HO-1 were high In the control group, the differences were statistically significant (P <0.05 or P <0.01). Conclusion Long-term exposure to low concentrations of chlorine may cause lung inflammation and adversely affect workers’ lung ventilation.